Brady throws 4 TDs, Patriots top Texans 42-14

FOXBOROUGH, Mass. (AP) — Just another game for the New England Patriots. Just a wire-to-wire domination of the team with the NFL's best record.

So when their 42-14 Monday night rout of the Houston Texans was complete, there were few big smiles and no loud music in the Patriots locker room.

They've been here before — many times.

"We've played in a countless number of big games," said guard Logan Mankins, a veteran of two of the Patriots five Super Bowls in the past 11 seasons. "We know what it takes to prepare for one and not over-hype the game."

Not exactly the way some Texans viewed it coming in — "the biggest game in the history of this franchise," wide receiver Andre Johnson had said.

Houston certainly didn't play like it, falling behind 21-0 early in the second quarter on three touchdown passes by Tom Brady. It was 28-0 on his fourth scoring toss just over five minutes into the third quarter and, with a strong showing by an improving Patriots defense, the Texans had little hope of coming back.

"If we do what we want," safety Devin McCourty said, "we can't predict the score but we know we can dominate games."

Starting with Brady.

He threw four touchdown passes for the 18th time, passing Johnny Unitas and moving into fourth place all time. In the Patriots seven-game winning streak — four by a margin of at least 28 points — he's thrown for 19 touchdowns and just one interception.

But Monday night's performance was his first as a father of three, capping off a stretch in which his wife, supermodel Gisele Bundchen, gave birth to Vivian Lake on Wednesday.

"She is doing very well," Brady said. "It's been a great week, a great way to end it."

The Patriots (10-3) tied the AFC West-leading Denver Broncos for the second best record in the conference and already have clinched the AFC East title. The Texans (11-2) still hold the top spot in the conference, and have locked up at least a wild-card berth, but two of their remaining three games are against Indianapolis, which trails them by two games in the AFC South.

"We know how important this game was to us," Johnson said after the Texans six-game winning streak ended. "We have to respond next week" against the Colts.

Wes Welker had only three catches and remains five short of becoming the first player with five 100-reception seasons. But his 31-yard punt return and 25-yard catch — the 107th straight game he's had at least one — led to the first of Aaron Hernandez's two touchdowns, a 7-yard score that gave Brady 45 consecutive games with a scoring pass, the third longest streak in NFL history.

Houston came right back, marching to the Patriots 21-yard line. But Matt Schaub forced the ball into double coverage on the next play and McCourty intercepted in the end zone.

It was the farthest the Texans would get until their second series of the third quarter that ended with Arian Foster's 1-yard scoring run that did little to shift the momentum.

"We just got outplayed in all aspects of the game," Foster said. "It's hard to come back from a deficit when you are playing a team of that caliber."

By the time he had scored, the Patriots had built a 28-0 lead on the 7-yard pass to Hernandez, a 37-yarder to Brandon Lloyd, a 4-yarder to Hernandez and a 63-yarder to Donte' Stallworth, who had been cut in training camp but re-signed last week after wide receiver Julian Edelman was injured.

"That particular play is something we had worked on, even in the spring," Stallworth said.

That helped New England to its 20th successive home win in December dating to a loss in 2002 to the New York Jets.

"It is always good to play in Foxborough in December," linebacker Jerod Mayo said. "When you go out and perform the way you do, I think Foxborough is going to be a tough place for anyone to come and play."

It certainly was for Houston, no longer the only team to be unbeaten on the road, falling to 6-1.

Brady nearly had a fifth touchdown pass when Danny Woodhead broke free on a screen pass early in the fourth quarter. Defensive end J.J. Watt, who was pretty much invisible otherwise, forced a fumble, but the ball soared 11 yards into the end zone, where Lloyd fell on it for a 35-7 lead.

Stevan Ridley made it 42-7 with a 14-yard run. Texans backup quarterback T.J. Yates scored on a 1-yard run with 2:00 remaining to close the scoring.

"We got our tails kicked," Houston coach Gary Kubiak said. "I've got to get their chins up and get ready to go play again."

Notes: Watt, who leads the AFC with 16½ sacks, had none against the Patriots. ... New England CB Aqib Talib hurt his hip in the second quarter. CB Alfonzo Dennard injured his hamstring. ... Brady completed 21 of 35 passes for 296 yards. Schaub went 19 for 32 for 232 yards. ... New England has won 10 games in each of the last 10 seasons. The record is 16 by San Francisco (1983-98).

___

Online: http://pro32.ap.org/poll and http://twitter.com/AP_NFL

Read More..

Personal Health: When Daily Stress Gets in the Way of Life

I was about to give an hourlong talk to hundreds of people when one of the organizers of the event asked, “Do you get nervous when you give speeches?” My response: Who, me? No. Of course not.

But this was a half-truth. I am a bit of a worrier, and one thing that makes me anxious is getting ready for these events: fretting over whether I’ve prepared the right talk, packed the right clothes or forgotten anything important, like my glasses.

Anxiety is a fact of life. I’ve yet to meet anyone, no matter how upbeat, who has escaped anxious moments, days, even weeks. Recently I succumbed when, rushed for time just before a Thanksgiving trip, I was told the tires on my car were too worn to be driven on safely and had to be replaced.

“But I have no time to do this now,” I whined.

“Do you have time for an accident?” my car-savvy neighbor asked.

So, with a pounding pulse and no idea how I’d make up the lost time, I went off to get new tires. I left the car at the shop and managed to calm down during the walk home, which helped me get back to the work I needed to finish before the trip.

It seems like such a small thing now. But everyday stresses add up, according to Tamar E. Chansky, a psychologist in Plymouth Meeting, Pa., who treats people with anxiety disorders.

You’ll be much better able to deal with a serious, unexpected challenge if you lower your daily stress levels, she said. When worry is a constant, “it takes less to tip the scales to make you feel agitated or plagued by physical symptoms, even in minor situations,” she wrote in her very practical book, “Freeing Yourself From Anxiety.”

When Calamities Are Real

Of course, there are often good reasons for anxiety. Certainly, people who lost their homes and life’s treasures — and sometimes loved ones — in Hurricane Sandy can hardly be faulted for worrying about their futures.

But for some people, anxiety is a way of life, chronic and life-crippling, constantly leaving them awash in fears that prevent them from making moves that could enrich their lives.

In an interview, Dr. Chansky said that when real calamities occur, “you will be in much better shape to cope with them if you don’t entertain extraneous catastrophes.”

By “extraneous,” she means the many stresses that pile up in the course of daily living that don’t really deserve so much of our emotional capital — the worrying and fretting we spend on things that won’t change or simply don’t matter much.

“If you worry about everything, it will get in the way of what you really need to address,” she explained. “The best decisions are not made when your mind is spinning out of control, racing ahead with predictions about how things are never going to get any better. Precious energy is wasted when you’re always thinking about the worst-case scenarios.”

When faced with serious challenges, it helps to narrow them down to specific things you can do now. To my mind, Dr. Chansky’s most valuable suggestion for emerging from paralyzing anxiety when faced with a monumental task is to “stay in the present — it doesn’t help to be in the future.

“Take some small step today, and value each step you take. You never know which step will make a difference. This is much better than not trying to do anything.”

Dr. Chansky told me, “If you’re worrying about your work all the time, you won’t get your work done.” She suggested instead that people “compartmentalize.” Those prone to worry should set aside a little time each day simply to fret, she said — and then put aside anxieties and spend the rest of the time getting things done. This advice could not have come at a better time for me, as I faced holiday chores, two trips in December, and five columns to write before leaving mid-month. Rather than focusing on what seemed like an impossible challenge, I took on one task at a time. Somehow it all got done.

Possible Thinking

Many worriers think the solution is positive thinking. Dr. Chansky recommends something else: think “possible.”

“When we are stuck with negative thinking, we feel out of options, so to exit out of that we need to be reminded of all the options we do have,” she writes in her book.

If this is not something you can do easily on your own, consult others for suggestions. During my morning walk with friends, we often discuss problems, and inevitably someone comes up with a practical solution. But even if none of their suggestions work, at least they narrow down possible courses of action and make the problem seem less forbidding. “If other people are not caught in the spin that you’re in, they may have ideas for you that you wouldn’t think of,” Dr. Chansky said. “We often do this about small things, but when something big is going on, we hesitate to ask for advice. Yet that’s when we need it most.”

Dr. Chansky calls this “a community cleanup effort,” and it can bring more than advice. During an especially challenging time, like dealing with a spouse’s serious illness or loss of one’s home, friends and family members can help with practical matters like shopping for groceries, providing meals, cleaning out the refrigerator or paying bills.

“People want to help others in need — it’s how the world goes around,” she said. Witness the many thousands of volunteers, including students from other states on their Thanksgiving break, who prepared food and delivered clothing and equipment to the victims of Hurricane Sandy. Even the smallest favor can help buffer stress and enable people to focus productively on what they can do to improve their situation.

Another of Dr. Chansky’s invaluable tips is to “let go of the rope.” When feeling pressured to figure out how to fix things now, “walk away for a few minutes, but promise to come back.” As with a computer that suddenly misbehaves, Dr. Chansky suggests that you “unplug and refresh,” perhaps by “taking a breathing break,” inhaling and exhaling calmly and intentionally.

“The more you practice calm breathing, the more it will be there for you when you need it,” she wrote.

She also suggests taking a break to do something physical: “Movement shifts the moment.” Take a walk or bike ride, call a friend, look through a photo album, or do some small cleaning task like clearing off your night table.

When you have a clear head and are feeling less overwhelmed, you’ll be better able to figure out the next step.

This is the first of two columns about anxiety.

Read More..

Boeing 787 Plane Works to Overcome Snags

Stuart Isett for The New York Times

The upper deck of a Boeing 787 Dreamliner being assembled in Everett, Wash. The basic model, called the 787-8, can carry 210 to 250 passengers.

After years of delays in producing its much-anticipated 787 aircraft, Boeing seemed in recent months to be turning a corner, streamlining production and increasing the pace of deliveries.

But a pair of embarrassing problems last week revived concerns about the reliability of the plane, the first commercial aircraft to make extensive use of lightweight carbon composites that promise big fuel savings for airlines.

A United Airlines 787 flying from Houston to Newark was diverted to New Orleans last Tuesday after one of its six electric generators failed midflight. That same day, the Federal Aviation Administration ordered inspections of fuel line connectors on all 787s, warning of a risk of fuel leaks and fires.

Aviation experts cast these issues as minor hiccups and said it was typical for new planes to experience such problems, particularly in the first few years of production.

On Monday, an aerospace analyst, David E. Strauss of UBS, raised another concern — whether the cost of building the planes was coming down fast enough for individual plane sales to become profitable by early 2015, as Boeing has projected.

Boeing officials have said that the company will earn enough on subsequent sales to average a percentage profit in the low single digits on the first 1,100 planes, which includes deliveries into 2021. Company officials said late Monday that they remained confident in their projections.

But in a research report, Mr. Strauss said that Boeing’s costs did not appear to be declining rapidly enough for sales to turn profitable in 2015 and that the program could continue to spend $4 billion to $5 billion more than it gained in revenue over the next three years. Unless the company can bring down the costs more quickly as it gains experience in building the planes, Mr. Strauss wrote, Boeing may not begin to make a profit on each plane until 2021.

A lot is riding on the success of the 787 Dreamliner, a risky technological and commercial bet for Boeing, which is based in Chicago. The company has so far delivered 38 of the jets to eight airlines, including United Airlines, All Nippon Airways of Japan and Poland’s LOT. It has outlined ambitious plans to double its production rate to 10 planes a month by the end of 2013. It is also starting to build a stretched-out version and mulling an even larger one after that, to make the venture more profitable.

But with the combination of the problem on the United flight and the F.A.A. directive, “This was too much news about the 787 in one day,” said Addison Schonland, an aviation analyst and a partner at Airinsight.com. “But remember, it’s a brand-new airplane. When you start flying it around, you start discovering things. Over all, the number of hiccups has been fantastic.”

The basic model, called the 787-8, can carry 210 to 250 passengers about 8,000 nautical miles, the distance from New York to Singapore, and has a list price of $206.8 million. Early customers, however, are receiving big discounts to make up for the delays caused by a series of manufacturing problems. The first stretched version for 250 to 290 passengers, the 787-9, is listed at $243.6 million and could be ready in early 2014.

Mr. Strauss estimated that Boeing was recently spending $232 million to build each plane but charged customers, on average, only about half that.

Given Wall Street’s concerns, Boeing’s stock has been in limbo for more than three years, trading in a narrow range around $75 a share.

“Boeing has not had a major snafu on the 787 for over a year now, but we think most investors remain skeptical as to whether Boeing can keep this up,” Robert Stallard, an analyst at RBC Capital Markets, said in a note to clients last month.

Boeing has acknowledged that it outsourced too much of the work on the plane to suppliers who were willing, collectively, to cover billions of dollars of the development costs. Many parts needed reworking. That and other design changes forced the company to set up a separate line in Everett, Wash., to handle the extra work on the first 65 jets. It has also built a 787 plant in Charleston, S.C., with an entirely new work force.

Still, even with all of the headaches, the 787 has enabled Boeing to jump ahead of its European rival, Airbus, in exploiting the lightweight carbon composites. Half of the plane by weight is made with composites instead of aluminum and other metals. Airbus said last week that it had finished assembly on the first A350, its rival to the 787. Its entry into commercial service is not expected before the second half of 2014.

Passengers who have flown on 787s this year have raved about the experience, and the first airlines using them also seem satisfied.

United will begin using the 787 internationally in January, with flights from Houston to Lagos, Nigeria. “There is a tremendous amount of promise for customers preferring this airplane over others,” said Jeff Smisek, chief executive of United. “It still has a new-plane smell.”

Read More..

Iran Has Rosy View of Unrest in Syria

TEHRAN — When Syria’s agricultural minister, Subhi Ahmad al-Abdullah, arrived in the Iranian capital for a visit last week, everybody involved stuck to a well-worn script.

There were welcoming ceremonies, handshakes in front of cameras and tête-à-têtes on rococo chairs. Stern-faced Iranian and Syrian officials discussed “expanding economic and agricultural ties” and signed a contract for the joint production of a vaccine for foot-and-mouth disease.

The unrest in Syria did not go unmentioned in the meetings, which were widely reported by Iranian state media. Iran’s vice president, Mohammad-Reza Rahimi, said Iran was confident of victory for the Syrian government forces, who, he said, were engaged in “sporadic fights with terrorists sent by regional countries.”

The upbeat ceremonies surrounding Mr. Abdullah’s visit illustrate how Iranian leaders perceive the bloody conflict that has engulfed their main ally in the Arabic world. While former Iranian diplomats, academics and analysts increasingly warn that President Bashar al-Assad’s government is on the brink of collapse, the country’s highest leaders insist the conflict is manageable and ultimately will be resolved to Iran’s advantage.

“We say that Bashar al-Assad, or at least his government, is the safest bet for stability and security in Syria,” said Amir Mohebbian, a political analyst whose views are sometimes published on the Web site of Iran’s supreme leader, Ayatollah Ali Khamenei. “If the foreign mercenaries take over, there will be a blood bath in Syria.”

Endless news broadcasts by Iran’s state television offer an ideological narrative in which Saudi Arabia and Qatar are doing the bidding of the United States and Israel, helping to arm foreign “terrorists” and sending them into Syria to punish it for having opposed Israel. War crimes committed by Syrian forces go unreported.

“Clearly, there is no real alternative for al-Assad and his government in Syria,” Mr. Mohebbian said. “They have agreed to reforms; there will be a multiparty system in Syria. So foreign countries should stop arming terrorists and let the Syrian people decide their own future.”

Some former diplomats, analysts and academics disagree with the blind support of Syria’s government. But they have little, if any, influence on Iran’s policy makers, who are mostly rigid ideologues.

“The Syrian Army is on the brink of complete collapse, and the downfall of al-Assad is inevitable,” Ebrahim Yazdi, a former foreign minister who is a member of the opposition, wrote Saturday in the newspaper Etemaad, which is critical of Iran’s government. “Syria’s leaders respond to reforms with bloody crackdowns. Their future is very bleak.”

Mashallah Shamsolvaezin, a Middle East analyst who has been imprisoned for his involvement in Iran’s opposition movement, echoed that view. “In reality, Syria will be in turmoil for years to come,” he said. “There will be nothing left of our anti-Israel front.”

Iran has organized two conferences for what it calls the “genuine” Syrian opposition, pushing for modest political changes, followed by nationwide presidential elections in 2014, as the only solution to stop the fighting.

Off the record, Iranian officials sometimes hint that Mr. Assad, as a symbol, could be sacrificed in Iran’s future vision for the country. But they insist that his political and security apparatus should remain in power, continuing to lead Syria as a regional spear against Iran’s archnemesis, Israel.

“We are seeking a peaceful solution in which the Syrian government implements reforms,” said Hamidreza Taraghi, a politician who is close to Iran’s leaders. “But whatever the cost, we want to keep Syria in the group of resistance against Israel.”

Mr. Taraghi, who recently led an Iranian delegation to North Korea and met with the country’s leader, Kim Jong-un, said that Iran was willing to do “whatever it takes” to keep Syria as an ally. He said the Syrian government had not yet asked Iran for military help, but if that happened Iran would be compelled by its treaty with Syria to step in.

Ramtin Rastin contributed reporting.

Read More..

HTC still tripping Samsung up in Windows Phone race

It is not clear that Samsung (005930) even cares — but HTC (2498) continues outmaneuvering its far bigger rival when it comes to Windows Phones. The budget HTC Windows Phone 8S is no available from UK operator Three starting at the notably low £17 per month contract price. This is about half of what the monthly contract price of Samsung’s ATIV S Windows Phone model is expected to cost in the UK. Once it finally arrives. Possibly during the last week of the year. There is no firm word on when ATIV S might arrive on AT&T (T) and Verizon (VZ) at this point.

So not only did Samsung miss the U.S. and European Christmas sales seasons completely with its first Windows Phone 8 device, HTC actually managed to get both the high-end Windows Phone 8X and the budget 8S out before Christmas in some key markets. And Three now actually seems to be giving robust marketing support for HTC’s Windows Phone devices. They are featured prominently on the website and 8X buyers get a free Windows Pro upgrade for their PCs.

It is worth noting that the Windows Phone 8S looks very competitive in the UK prepaid market with a £180 price tag at Three. The Samsung Galaxy S Advance  is £270 and Nokia’s (NOK) Lumia 710 is £200.

HTC recently started looking like Jessica Biel — too bland and too expensive — but with the 8S, it might be getting some of its European budget groove back. It is now starting to look like the November sales momentum HTC just showed will extend to December.

Get more from BGR.com: Follow us on Twitter, Facebook

Wireless News Headlines – Yahoo! News

Read More..

RG3 hurts knee, but Skins beat Ravens 31-28 in OT

LANDOVER, Md. (AP) — This, of course, is the sort of thing everyone associated with — and rooting for — the Washington Redskins worries about: Robert Griffin III limping to the sideline after a knee-spraining hit.

With the Redskins driving while trailing the Baltimore Ravens late in the fourth quarter of a game Washington would wind up winning 31-28 in overtime Sunday, Griffin was slow to rise after being tackled at the end of a 13-yard scramble.

"I screamed. Like a man, of course," Griffin said with a laugh, before acknowledging: "It hurt really bad."

He left for one play, then returned for four more. But by then, the No. 2 overall pick in this year's NFL draft was hopping on his left leg, keeping all weight off his injured right one. Eventually, Griffin knelt on the turf, unable to continue.

"I knew I needed to get out at that point," said last year's Heisman Trophy winner, who had an MRI exam later Sunday that didn't show significant ligament damage. "I couldn't move. At some point, you have to do what's right for the team. And if I'm playing the rest of that game, I probably would have hurt myself even more."

Said Redskins coach Mike Shanahan: "I could see that he was hurting the second time he came out. You could see his face."

So whatever euphoria the Redskins (7-6) and their fans might have been feeling following a fourth consecutive victory was mixed with concern about the sight of the man they call RG3 hobbling around on the sideline with a thick, black brace on his right knee as Kai Forbath kicked a 34-yard field goal to end the game.

"We're happy that we won, obviously," left tackle Trent Williams said. "But that is concerning, knowing he went down. Everyone wants to know how he's doing."

About three hours after the game, an answer arrived: Team spokesman Tony Wyllie said the MRI showed that while Griffin sprained his knee, "everything is clear" in terms of a major knee injury. Wyllie specifically ruled out a season-ending ACL tear, such as the one Griffin had on the same knee while playing in college at Baylor in 2009.

Still, because a sprained knee, by definition, means at least one of the several ligaments is damaged in some way, it's not clear what Griffin's status for next week at the Cleveland Browns will be.

"Everybody's praying for me. I feel pretty good right now about the whole situation," said Griffin, who left a game earlier this season because of a concussion.

With Griffin done for the day, and Baltimore — now 9-4 after its first consecutive losses since early in the 2009 season — leading 28-20, fellow rookie QB Kirk Cousins stepped in. Cousins, a fourth-round pick who only played in one other game this season, threw an 11-yard touchdown pass to Pierre Garcon with 29 seconds remaining in regulation, then ran a quarterback draw for the tying 2-point conversion.

"He's ice. Like they used to say about Larry Bird, he got ice water in his veins. That's the best thing you can say about Kirk," receiver Joshua Morgan said.

Griffin heard the call for Cousin's draw through his headphones while getting treatment on the sideline.

"It was awesome," said Griffin, who was 15 for 26 for 246 yards and a touchdown pass, along with 34 yards on seven carries, adding to his single-season record for rushing by a rookie quarterback.

Ravens safety Ed Reed said his defense was ready for that 2-point play, actually, but "we didn't execute."

The Ravens got the ball first in overtime but went three-and-out. Yet another Redskins rookie, Richard Crawford, returned the punt 64 yards to set up Forbath, who is now 14 for 14 to start his NFL career; each got a game ball from Shanahan.

While Washington remained one game behind the New York Giants (8-5) in the race for the NFC East title, the Ravens wasted a chance to clinch the AFC North — and even missed out on an opportunity to assure themselves of a playoff berth.

Joe Flacco completed 16 of 21 passes for 182 yards and three first-half TD passes that built a 21-14 lead. But Baltimore's first four drives of the second ended with Flacco's fumble, his interception deep in Washington's territory, and two three-and-outs.

"As a leader on this team I like to finish teams out," said Ray Rice, who finished with 121 yards on 20 carries but picked up a left hip pointer. "I don't want to be known as, 'Yeah, we get them close in the fourth quarter, and the Ravens are going to give it away.' That's never been us. That's not going to be us."

Rice's 7-yard touchdown run with 4:47 to play in the fourth quarter put the Ravens up by eight points, before Griffin started the trying drive — and Cousins finished it.

Forbath's winning kick prompted a wild on-field celebration by many Redskins. Not Griffin, though. He gingerly walked toward the locker room, a brace on his knee, and flashed a thumb's up to raucous spectators in the stands.

Later, around the Redskins announced the results of his good-news MRI, Griffin tweeted: "Your positive vibes and prayers worked people!!!!"

NOTES: Cousins completed both passes he threw. ... Ravens RG Marshal Yanda sprained his right ankle and was wearing a black walking boot on that foot in the locker room. Other injuries for Baltimore: LB Jameel McClain had a neck injury, but X-rays were negative. ... Washington's 186 yards were the most by any NFL team in the first quarter this season and the most by the franchise in that quarter since 1997. ... The Redskins hadn't won four games in a row since 2008.

___

Connect with Howard Fendrich on Twitter at http://twitter.com/HowardFendrich

___

Online: http://pro32.ap.org/poll and http://twitter.com/AP_NFL

Read More..

A Breakthrough Against Leukemia Using Altered T-Cells

PHILIPSBURG, Pa. — Emma Whitehead has been bounding around the house lately, practicing somersaults and rugby-style tumbles that make her parents wince.

It is hard to believe, but last spring Emma, then 6, was near death from leukemia. She had relapsed twice after chemotherapy, and doctors had run out of options.

Desperate to save her, her parents sought an experimental treatment at the Children’s Hospital of Philadelphia, one that had never before been tried in a child, or in anyone with the type of leukemia Emma had. The experiment, in April, used a disabled form of the virus that causes AIDS to reprogram Emma’s immune system genetically to kill cancer cells.

The treatment very nearly killed her. But she emerged from it cancer-free, and about seven months later is still in complete remission. She is the first child and one of the first humans ever in whom new techniques have achieved a long-sought goal — giving a patient’s own immune system the lasting ability to fight cancer.

Emma had been ill with acute lymphoblastic leukemia since 2010, when she was 5, said her parents, Kari and Tom. She is their only child.

She is among just a dozen patients with advanced leukemia to have received the experimental treatment, which was developed at the University of Pennsylvania. Similar approaches are also being tried at other centers, including the National Cancer Institute and Memorial Sloan-Kettering Cancer Center in New York.

“Our goal is to have a cure, but we can’t say that word,” said Dr. Carl June, who leads the research team at the University of Pennsylvania. He hopes the new treatment will eventually replace bone-marrow transplantation, an even more arduous, risky and expensive procedure that is now the last hope when other treatments fail in leukemia and related diseases.

Three adults with chronic leukemia treated at the University of Pennsylvania have also had complete remissions, with no signs of disease; two of them have been well for more than two years, said Dr. David Porter. Four adults improved but did not have full remissions, and one was treated too recently to evaluate. A child improved and then relapsed. In two adults, the treatment did not work at all. The Pennsylvania researchers were presenting their results on Sunday and Monday in Atlanta at a meeting of the American Society of Hematology.

Despite the mixed results, cancer experts not involved with the research say it has tremendous promise, because even in this early phase of testing it has worked in seemingly hopeless cases. “I think this is a major breakthrough,” said Dr. Ivan Borrello, a cancer expert and associate professor of medicine at the Johns Hopkins University School of Medicine.

Dr. John Wagner, the director of pediatric blood and marrow transplantation at the University of Minnesota, called the Pennsylvania results “phenomenal” and said they were “what we’ve all been working and hoping for but not seeing to this extent.”

A major drug company, Novartis, is betting on the Pennsylvania team and has committed $20 million to building a research center on the university’s campus to bring the treatment to market.

Hervé Hoppenot, the president of Novartis Oncology, called the research “fantastic” and said it had the potential — if the early results held up — to revolutionize the treatment of leukemia and related blood cancers. Researchers say the same approach, reprogramming the patient’s immune system, may also eventually be used against tumors like breast and prostate cancer.

To perform the treatment, doctors remove millions of the patient’s T-cells — a type of white blood cell — and insert new genes that enable the T-cells to kill cancer cells. The technique employs a disabled form of H.I.V. because it is very good at carrying genetic material into T-cells. The new genes program the T-cells to attack B-cells, a normal part of the immune system that turn malignant in leukemia.

The altered T-cells — called chimeric antigen receptor cells — are then dripped back into the patient’s veins, and if all goes well they multiply and start destroying the cancer.

The T-cells home in on a protein called CD-19 that is found on the surface of most B-cells, whether they are healthy or malignant.

A sign that the treatment is working is that the patient becomes terribly ill, with raging fevers and chills — a reaction that oncologists call “shake and bake,” Dr. June said. Its medical name is cytokine-release syndrome, or cytokine storm, referring to the natural chemicals that pour out of cells in the immune system as they are being activated, causing fevers and other symptoms. The storm can also flood the lungs and cause perilous drops in blood pressure — effects that nearly killed Emma.

Steroids sometimes ease the reaction, but they did not help Emma. Her temperature hit 105. She wound up on a ventilator, unconscious and swollen almost beyond recognition, surrounded by friends and family who had come to say goodbye.

But at the 11th hour, a battery of blood tests gave the researchers a clue as to what might help save Emma: her level of one of the cytokines, interleukin-6 or IL-6, had shot up a thousandfold. Doctors had never seen such a spike before and thought it might be what was making her so sick.

Dr. June knew that a drug could lower IL-6 — his daughter takes it for rheumatoid arthritis. It had never been used for a crisis like Emma’s, but there was little to lose. Her oncologist, Dr. Stephan A. Grupp, ordered the drug. The response, he said, was “amazing.”

Within hours, Emma began to stabilize. She woke up a week later, on May 2, the day she turned 7; the intensive-care staff sang “Happy Birthday.”

Since then, the research team has used the same drug, tocilizumab, in several other patients.

In patients with lasting remissions after the treatment, the altered T-cells persist in the bloodstream, though in smaller numbers than when they were fighting the disease. Some patients have had the cells for years.

Dr. Michel Sadelain, who conducts similar studies at the Sloan-Kettering Institute, said: “These T-cells are living drugs. With a pill, you take it, it’s eliminated from your body and you have to take it again.” But T-cells, he said, “could potentially be given only once, maybe only once or twice or three times.”

The Pennsylvania researchers said they were surprised to find any big drug company interested in their work, because a new batch of T-cells must be created for each patient — a far cry from the familiar commercial strategy of developing products like Viagra or cholesterol medicines, in which millions of people take the same drug.

Read More..

Bloomberg Weighs Making a Run for Financial Times

Not long ago, The Financial Times would have been the crown jewel of any media company, instantly conferring prestige and influence on its owner. Now, given the likely bidders, one of the world’s most respected and distinctive financial newspapers could end up as a trophy to help sell more computer terminals.

Michael R. Bloomberg is weighing the wisdom of buying The Financial Times Group, which includes the paper and a half interest in The Economist, according to three people close to Mr. Bloomberg who spoke on the condition of anonymity to divulge private conversations.

Mr. Bloomberg has long adored The Economist, and his affinity for The Financial Times, at least as a reader, has deepened lately. Its bisque-colored pages, once rarely seen in the thick stack of newspapers Mr. Bloomberg carries under his arm all day, have become a mainstay. Friends say he favors its generally short, punchy and to-the-point articles, which match his temperament.

In October, Mr. Bloomberg visited the London headquarters of The Financial Times, a few blocks away from Bloomberg L.P.’s giant new London complex, which is still under construction. When an editor asked if he would buy the paper, Mr. Bloomberg replied, “I buy it every day.”

He has spoken openly with friends and aides about the potential benefits and pitfalls of making such a costly acquisition in an industry he admires deeply as a reader but sneers at as a businessman, these same people said. And he has recently taken to rattling off circulation figures and “penetration” rates for the paper.

“It’s the only paper I’d buy,” he has said to one associate. “Why should I buy it?” he has asked another.

His ambivalence speaks to the troubles facing the newspaper business, and to the complex motivations of the mayor himself. Drawn to power and prominence, Mr. Bloomberg is wrestling with his affection for the paper as its potential publisher and his wariness of an investment that could mar his company’s reputation for achieving outsize profits. Pearson, the parent company of The Financial Times Group, does not break out separate financial results for the paper, but analysts estimate that it loses money. A spokesman for the mayor declined to comment on his conversations about the paper.

For Thomson Reuters, the other likely bidder, the calculation is somewhat different. Unlike Mr. Bloomberg, who started his financial information company in 1982, James C. Smith, president and chief executive of Thomson Reuters, came up through Thomson’s regional newspapers and has ink in his veins. A replica of an old-fashioned printing press is on display in his corner office overlooking Times Square.

But the company has been hurt financially after its newest desktop terminal product struggled to catch on. In the first nine months of 2012, the company reported revenue of $9.88 billion, a 3 percent decrease from the period a year earlier. A company spokesman declined to comment.

The Financial Times could expand the Thomson Reuters brand and give its reporters additional exposure since, unlike Bloomberg, which bought Businessweek in 2009, the company does not own a regular magazine. Thomson Reuters, partly a British company, and The Financial Times also have large footprints in Asia.

But first, the paper needs to be put on the block. Pearson is about to lose two of its top executives, raising speculation the paper could be for sale. Analysts value The Financial Times Group at about $1.2 billion, well within the reach of Bloomberg L.P., which in 2011 had revenue of $7.6 billion, and Thomson Reuters, which posted revenue of $13.8 billion.

The paper has a successful digital strategy, and analysts have said that its strict online pay wall is considered a financial success. But like most newspapers, it is struggling in an industrywide decline in print advertising revenue. In the three months ending Oct. 1, the paper’s total paid circulation exceeded 600,000, more than half of which was from digital subscriptions. In its most recent earnings report, Pearson said it expected profit to decline because of a sluggish advertising market and “the shift from print to digital.”

Marjorie Scardino, Pearson’s longtime chief executive, who once said the paper would be sold “over my dead body,” is departing on Dec. 31. Rona Fairhead, chief executive of The Financial Times Group, will leave at the end of April. Both executives had championed the print businesses. A successor to Ms. Fairhead has yet to be named, though one person close to the company pointed to John Ridding, the chief executive of the paper.

Read More..

Syrian Rebels Tied to Al Qaeda Play Key Role in War

Sana Handout, via European Pressphoto Agency

In May in Damascus, Syrian workers removed debris from two car bombs that were linked to the Qaeda-backed Nusra Front.

BAGHDAD — The lone Syrian rebel group with an explicit stamp of approval from Al Qaeda has become one of the uprising’s most effective fighting forces, posing a stark challenge to the United States and other countries that want to support the rebels but not Islamic extremists.

Money flows to the group, the Nusra Front, from like-minded donors abroad. Its fighters, a small minority of the rebels, have the boldness and skill to storm fortified positions and lead other battalions to capture military bases and oil fields. As their successes mount, they gather more weapons and attract more fighters.

The group is a direct offshoot of Al Qaeda in Iraq, Iraqi officials and former Iraqi insurgents say, which has contributed veteran fighters and weapons.

“This is just a simple way of returning the favor to our Syrian brothers that fought with us on the lands of Iraq,” said a veteran of Al Qaeda in Iraq, who said he helped lead the Nusra Front’s efforts in Syria.

The United States, sensing that time may be running out for Syria’s president, Bashar al-Assad, hopes to isolate the group to prevent it from inheriting Syria or fighting on after Mr. Assad’s fall to pursue its goal of an Islamic state.

As the United States pushes the Syrian opposition to organize a viable alternative government, it plans to blacklist the Nusra Front as a terrorist organization, making it illegal for Americans to have financial dealings with the group and most likely prompting similar sanctions from Europe. The hope is to remove one of the biggest obstacles to increasing Western support for the rebellion: the fear that money and arms could flow to a jihadi group that could further destabilize Syria and harm Western interests.

When rebel commanders met Friday in Turkey to form a unified command structure at the behest of the United States and its allies, jihadi groups were not invited.

The Nusra Front’s ally, Al Qaeda in Iraq, is the Sunni insurgent group that killed numerous American troops in Iraq and sowed widespread sectarian strife with suicide bombings against Shiites and other religious and ideological opponents. The Iraqi group played an active role in founding the Nusra Front and provides it with money, expertise and fighters, said Maj. Faisal al-Issawi, an Iraqi security official who tracks jihadi activities in Iraq’s Anbar Province. 

But blacklisting the Nusra Front could backfire. It would pit the United States against some of the best fighters in the insurgency that it aims to support. While some Syrian rebels fear the group’s growing power, others work closely with it and admire it — or, at least, its military achievements — and are loath to end their cooperation.

Leaders of the Free Syrian Army, the loose-knit rebel umbrella group that the United States seeks to bolster, expressed exasperation that the United States, which has refused to provide weapons throughout the conflict that has killed more than 40,000 people, is now opposing a group they see as a vital ally.

The Nusra Front “defends civilians in Syria, whereas America didn’t do anything,” said Mosaab Abu Qatada, a rebel spokesman. “They stand by and watch; they look at the blood and the crimes and brag. Then they say that Nusra Front are terrorists."

He added, “America just wants a pretext to intervene in Syrian affairs after the revolution.”

The United States has been reluctant to supply weapons to rebels that could end up in the hands of anti-Western jihadis, as did weapons that Qatar supplied to Libyan rebels with American approval. Critics of the Obama administration’s Syria policy counter that its failure to support the rebels helped create the opening that Islamic militants have seized in Syria.

The Nusra Front’s appeals to Syrian fighters seem to be working.

At a recent meeting in Damascus, Abu Hussein al-Afghani, a veteran of insurgencies in Afghanistan, Iraq and Libya, addressed frustrated young rebels. They lacked money, weapons and training, so they listened attentively.

He told them he was a leader of Al Qaeda in Iraq, now working with a Qaeda branch in Syria, and by joining him, they could make their mark. One fighter recalled his resonant question: “Who is hearing your voice today?”

On Friday, demonstrators in several Syrian cities raised banners with slogans like, “No to American intervention, for we are all Jebhat al-Nusra,” referring to the group’s full name, Ansar al-Jebhat al-Nusra li-Ahl al-Sham, or Supporters of the Front for Victory of the People of Syria. One rebel battalion, the Ahrar, or Free Men, asked on its Facebook page why the United States did not blacklist Mr. Assad’s “terrorist” militias.

Another jihadist faction, the Sahaba Army in the Levant, even congratulated the group on the “great honor” of being deemed terrorists by the United States.

Tim Arango reported from Baghdad, and Anne Barnard and Hwaida Saad from Beirut, Lebanon. Reporting was contributed by Hania Mourtada from Beirut; Duraid Adnan and Yasir Ghazi from Baghdad; employees of The New York Times from Mosul, Iraq, and the provinces of Anbar and Diyala; and Michael R. Gordon from Dublin.

Read More..

How one startup is overhauling Android to make it enterprise-ready

The common misconception that Android isn’t secure enough for the business world or government employees is about to change. A Boston-based startup called Optio Labs has created a custom version of Google’s (GOOG) mobile operating system that can control what can and cannot be accessed depending on location, network or running apps. The technology can even allow a phone to display sensitive company data or block things like texting and camera usage based on room-specific security and access settings, Technology Review reported. This unique feature can utilize a Bluetooth beacon that, when in range, would send a cryptographic tether to a device. It would also be possible to use near field communications to view sensitive information, theoretically forcing workers to “bump” their bosses phone to get initial access.

“You can dream up just about any rule, it can be your GPS location, or an indoor location detection: when you are in this specific room you can use these apps and connect to this data, but the moment you walk out we will delete the data, shut down the apps, prevent you from getting access to them,” said Jules White, co-founder of the company.

The technology could prevent information from being lost or stolen and can increase productivity by stopping workers from texting and spending time on social networking sites while in the office. Optio Labs is said to have sold its custom Android software and accompanying policy-management system to undisclosed systems integrators and smartphone manufacturers. Android devices containing the software are expected to arrive on the market in late 2013.

Get more from BGR.com: Follow us on Twitter, Facebook

Wireless News Headlines – Yahoo! News

Read More..